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Journal of Antimicrobial Chemotherapy (1995) 36, 231-236
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Effect on Pseudomonas aeruginosa alginate expression of direct plating and culture of fresh cystic fibrosis sputum on to pseudomonas isolation agar containing subinhibitory concentrations of roxithromycin and rifampicin

Marie-Josée Dupont and Jean-Rock Lapointe*

Research Center and Department of Microbiology and Immunology, Université de Montréal, and Hôpital Ste-Justines Montreal Quebec, H3T IC5, Canada

Received 1 February 1994; returned 11 October 1994; accepted 13 February 1995

*Correspondence to: Dr Jean-Rock Lapointe, Laboratoire d'antibiotiques, Départment de Microbiologie et Immunologie, Hôpital Ste-Justine, 3175, chemin de la Côte Ste-Catherine, Montréal, Québec, Canada, H3T 1C5. Phone: + (514) 345-4643 FAX: + (514) 345-4818

The effects of subinhibitory concentrations of roxithromycin (16 mg/L) or rifampicin (16 mg/L) on alginate production by Pseudomanas aeruginosa were investigated. The weight of purified alginate from antibiotic-free cultures was significantly greater (52.5 ± 24.0 mg, range 22.4-109.5), compared with alginate from cultures bacteria exposed to sub-MIC of roxithromycin (21-9 ± 17.0, 0.0-42.1 (P ≥ 0.037)) and to sub-MIC of rifampicin (28.6 ± 15.0, 2.9-47.5 (P ≥ 0.038)). Chromatographic analysis of hydrolysed and chemically transformed sub-units of alginate revealed that the presence and the molar ratio of D-mannuronic acid and L-guluronic acid were not affected in the remnant alginate exposed to sub-MIC of roxithromycin in contrast to that in the remnant alginate exposed to sub-MIC of rifampicin.


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