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Journal of Antimicrobial Chemotherapy (1995) 36, 225-230
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Susceptibility of enterococci, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae to the glycylcyclines

W. J. Weiss, N. V. Jacobus, P. J. Petersen and Raymond T. Testa*

Infectious Disease Research Section, Medical Research Division, American Cyanamid Company Pearl River, New York 10965, USA

Received 21 September 1994; returned 29 December 1994; accepted 14 February 1995

*Corresponding author. Phone: +1-(914)-73253463; Fax: +1-(914)-732 5536

The in-vitro activities of two glycylcyclines, DMG-MINO and DMG-DMDOT, and several comparative agents were determined against 263 enterococci, 102 methicillin-resistant Staphylococcus aureus and 55 Streptococcus pneumoniae recent clinical isolates. The glycylcyclines and teicoplanin were the most active agents against the enterococcal isolates. All methicillin-resistant S. aureus were susceptible to the glycylcyclines. Only DMG-DMDOT, ciprofloxacin, teicoplanin and vancomycin exhibited comparable activity against penicillin-susceptible, -intermediateand -resistant S. pneumoniae strains.


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