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Journal of Antimicrobial Chemotherapy (1995) 36, 209-213
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

SYN987, SYN1193, and SYN1253, new quinolones highly active against Gram-positive cocci

M. D. Kitzisa, F. W. Goldsteina, N. Ishidab and J. F. Acara

aFondation Hôpital Saint-Joseph, Laboratoire de Microbiologie Médicale 185 rue Raymond Losserand, 75674 Paris cedex 14, France bTaiho Laboratory Tokushima, Japan

Received 13 July 1994; returned 19 January 1995; accepted 28 February 1995

SYN987, 1193 and 1253 are new fluorinated quinolones with enhanced activity against Gram-positive bacteria. The MICs ofSYN 987, 1193 or 1253 were studied by an agar dilution method against 88 steptococci (including penicillin resistant Streptococcus pneumoniae), 30 enterococci and 62 Staphylococcus aureus. SYN 987, 1193 and 1253 were 2 to 4 times more active than sparfloxacin and 16–64 times more active than older fluoroquinolones against all streptococci and ciprofloxacin-resistant S. aureus. This study demonstrates that SYN 987, 1193 and 1253are extremely potent antibacterial agents which deserve further evaluation.


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