Journal of Antimicrobial Chemotherapy (1995) 35, 345-348
© 1995 The British Society for Antimicrobial Chemotherapy
brief-report |
Mutation position and type of substitution in the ß-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis
Institute for Medical Microbiology, University of Berne CH-3010 Bern, Switzerland
Received 14 June 1994; returned 1 September 1994; accepted 3 October 1994
Quantitative susceptibility testing for rifampicin, rifabutin and rifapentine of 36 Mycobacterium tuberculosis isolates with known sequences for the gene encoding for the RNA polymerase ß-subunit (rpoB)revealed that both mutation position and type of amino acid substitution influence the in-vitro activity of rifamycins in rifampicin-resistant strains.
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