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Journal of Antimicrobial Chemotherapy (1995) 35, 339-343
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

The in-vitro effect of temperature on MICs, bactericidal rates and postantibiotic effects in Staphylococcus aureus, Klebsiella Pneumoniae and Pseudomonas aeruginosa

V. Magnussona,b, Th. Jonsdottira,b, H. Gudmundsdottira, H. Erlendsdottira and S. Gudmundsson*,b,c

aDepartments of Clinical Microbiology, Borgarspitalinn (Reykjavik City Hospital) 108 Reykjavik bUniversity of Iceland Medical School 101 Reykjavik cDepartment of Medicine, Landspitalinn (University Hospital) 101 Reykjavik, Iceland

Received 26 April 1994; returned 18 August 1994; accepted 3 October 1994

*Corresponding author.

Varying temperatures (35·5°C, 38·5°C, 41°C) only minimally affected growth rates in vitro of Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa, as well as bactericidal rates and postantibiotic effects of several antibiotics. However, MICs were reduced at least four-fold by increasing temperature in 25% of the drug-organism combinations tested.


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