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Journal of Antimicrobial Chemotherapy (1995) 35, 333-337
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

The comparative inhibitory and bactericidal activities of meropenem and imipenem against Acinetobacter spp. and Enterobacteriaceae resistant to second generation cephalosporins

A. P. MacGowana, K. E. Bowkera, K. A. Bedforda, H. A. Holfa, D. S. Reevesa and A. Hedgesb

aRegional Antimicrobial Reference Laboratory, Department of Medical Microbiology, Southmead Health Services NHS Trust Westbury-on Trym, Bristol BS10 5NB bDepartment of Pathology and Microbiology, School of Medical Services, University of Bristol Bristol BS8 ITD, UK

Received 7 January 1994; returned 3 May 1994; accepted 14 June 1994

The inhibitory and bactericidal activities of meropenem and imipenem were compared using Acinetobacter spp. and Enterobacteriaceae resistant to second generation cephalosporins. The inhibitory activity of both agents was similar for Acinetobacter spp. but meropenem was more active against the Enterobacteriaceae. Bactericidal activities were compared employing time-kill curves which indicated meropenem was more bactericidal than imipenem against Enterobacteriaceae at pharmacologically achievable concentrations while imipenem was more bactericidal than meropenem against Acinetobacter spp.


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