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Journal of Antimicrobial Chemotherapy (1994) 34, 809-812
© 1994 The British Society for Antimicrobial Chemotherapy

brief-report

The pharmacokinetics of once daily gentamicin in neutropenic adults with haematological malignancy

A. P. MacGowana, K. A. Bedforda, E. Blundellb, N. M. Browna, F. Habiba, J. Howsb, B. Kirkpatricka, R. J. Kornera, R. R. Sladeb, L. O. Whitea and D. S. Reevesa

Regional Antimicrobial Reference Laboratory Bristol BS10 5NB, UK aDepartment of Medical Microbiology Bristol BS10 5NB, UK bDepartment of Haematology, Southmead Health Services NHS Trust, Westbury-on-Trym Bristol BS10 5NB, UK

Received 15 March 1994; accepted 14 June 1994

Seven febrile neutropenic adults with normal renal function were treated with intravenous gentamicin 4.5 mg/kg once a day in combination with azlocillin. Gentamicin serum concentrations 1, 2, 4, 8, and 24h after a 30 min infusion were 10.9 ± 0.6, 7.1 ± 0.4, 4.2 ± 0.2, 1.8 ±0.1 and 0.16 ± 0.003 mg/L respectively. The pharmacokinetics were best described by a triphasic plot including a distribution phase (about 1/2 h) and two elimination phases, an early and late.


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