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Journal of Antimicrobial Chemotherapy (1994) 34, 797-802
© 1994 The British Society for Antimicrobial Chemotherapy

brief-report

Treatment of experimental endocarditis due to multidrug resistant Enterococcus faecium with ciprofloxacin and novobiocin

John M. Quale, David Landman and Neville Mobarakai

Department of Medicine (111E), Brooklyn Veterans Administration Medical Center 800 Poly Place, Brooklyn, New York 11209, USA

Received 28 March 1994; accepted 11 July 1994

The effectiveness of ciprofloxacin and/or novobiocin therapy was assessed for experimental endocarditis caused by three strains of Enterococcus faecium resistant to ampicillin, vancomycin, and aminoglycosides. Rabbits with endocarditis caused by two of the strains had a significant decrease in bacterial counts in vegetations when treated with both antibiotics. Further studies using combination therapy with ciprofloxacin plus novobiocin for multidrug resistant strains of E. faecium are warranted.


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