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Journal of Antimicrobial Chemotherapy (1994) 34, 785-790
© 1994 The British Society for Antimicrobial Chemotherapy

brief-report

Comparison of antibiotic combinations against penicillin-resistant pneumococci

B. Cassinata and M. H. Nicolasb,*

aINSERM Unit 354, St. Antoine Hospital 184 rue du Faubourg St. Antoine, 75012 Paris bMicrobiology Department, Ambroise Paré Hospital 9 av. Charles de Gaulle, 92104 Boulogne Cedex, France

Received 16 August 1993; accepted 17 June 1994

*Corresponding author.

The isolation rate of penicillin resistant pneumococci is increasing in France. To date, cefotaxime and ceftriaxone are the two drugs recommended for the treatment of severe infections and oral third generation cephalosporins are frequently employed for the treatment of non-invasive pneumococcal diseases. In this study, we determined the bacteriostatic activity of 21 antibiotic combinations against 13 clinical isolates of Streptococcus pneumoniae with MICs ≥ 0.1 mg/L penicillin and 13 strains that were susceptible.


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