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Journal of Antimicrobial Chemotherapy (1994) 34, 777-783
© 1994 The British Society for Antimicrobial Chemotherapy

brief-report

Comparative in-vitro activity of piperacillin-tazobactam against recent clinical isolates, a Dutch national multicentre study

E. E. Stobberingha, D. M. Maclarenb, P. I. M. Schmitzc and The Multicentre Study Group*

aUniversity of Limburg, University Hospital Maastricht, Department of Medical Microbiology P.O. Box 5800, 6202 AZ Maastrict bUniversity Hospital, Free University Amsterdam, Department of Clinical Microbiology and Infection Control cDaniel den Hoed Cancer Center, Department of Trials & Statistics Rotterdam, the Netherlands

Received 9 December 1993; accepted 26 July 1994

In this Dutch national survey piperacillin-tazobactam had a MIC90of ≤8 mg/L for Enterobacteriaceae (Enterobacter cloacae excluded) and Pseudomonas aeruginosa, 64 mg/L for E. cloacae, and 4 mg/L, for Acinetobacter spp. The corresponding MIC90 values for piperacillin alone were ≤256 mg/L, 256 mg/L, 16 mg/L and 32 mg/L. Only 15 of 93 piperacillin-tazobactam resistant E. cloacae strains were sensitive for ceftazidime, whereas 41 of 93 ceftazidime-resistant E. cloacae were sensitive to piperacillin-tazobactam.


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