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Journal of Antimicrobial Chemotherapy (1994) 34, 639-648
© 1994 The British Society for Antimicrobial Chemotherapy

research-article

A multicentre study of the in-vitro activity of cefotaxime, cefuroxime, ceftazidime, ofloxacin and ciprofloxacin against blood and urinary pathogens

S. G. B. Amyesa, D. R. Bairdb, D. W. Crookc, S. H. Gillespled, A. J. Howarde, B. A. Oppenhiemf, S. J. Pedlerg, A. Paullh, D. S. Tompkinsi and S. A. Lawriej

aScottish Antibiotic Reference Laboratory, Department of Medical Microbiology, University of Edinburgh Edinburgh bDepartment of Bacteriology, Glasgow Royal Infirmary Glasgow cDepartment of Microbiology, John Radcliffe Hospital Oxford dDivision of Communicable Diseases, The Royal Free Hospital School of Medicine London eDepartment of Medical Microbiology, Gwynedd Hospital Bangor fMicrobiology Department, Withington Hospital Manchester gDepartment of Microbiology, The Royal Victoria Infirmary Newcastle upon Tyne hDepartment of Medical Microbiology, University Hospital of Wales Cardiff iDepartment of Microbiology, Bradford Royal Infirmary Bradford jRoussel Laboratories Ltd. Broadwater Park, North Orbital Road, Denham, Middlesex, UK

Received 12 August 1993; accepted 14 July 1994

The in-vitro susceptibilities of aerobic bacteria isolated from 1804 blood and 4529 urine specimens collected at nine hospitals in the UK were examined. An agar dilution method was used to determine the MICs of each isolate to three cephalosporins, cefotaxime, cefuroxime and ceftazidime, and to two fluoroquinolones, ofloxacin and ciprofloxacin. Sensitivities were then calculated using British Society for Antimicrobial Chemotherapy recommended breakpoints.

Of the cephalosporins tested cefotaxime was the most active against the Enterobacteriaceae. All the systemic staphylococcus isolates collected were sensitive to both cefotaxime and cefuroxime. As expected, ceftazidime was the only cephalosporin active against the Pseudomonas isolates.

Both quinolones were highly active against the Enterobacteriaceae and Pseudomonas spp. They also demonstrated good Gram-positive activity, particularly against Staphylococcus aureus and Enterococcus spp.


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