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Journal of Antimicrobial Chemotherapy (1994) 34, 629-637
© 1994 The British Society for Antimicrobial Chemotherapy

research-article

The in-vitro activity of FK-037, a new broad spectrum injectable cephalosporin

R. Wise, J. M. Andrews and D. Thornber

Department of Microbiology, Dudley Road Hospital Birmingham B18 7QH, UK

Received 21 February 1994; accepted 14 June 1994

The in-vitro activity of the parenteral cephem FK-037 was compared to those of cefpirome, ceftazidime, cefuroxime, cefixime, amoxycillin and co-amoxiclav. Against the Enterobacteriaceae FK-037 was generally ≥ 16-fold more active than cefuroxime and two- to four-fold more active than ceftazidime and similar in activity to cefpirome. Pseudomonas aeruginosa displayed similar susceptibilities to ceftazidime and FK-037 (MIC90 4 and 8mg/L respectively).

Methicillin-resistant Staphylococcus aureus were inhibited by ≤ 4 mg/L of FK-037. The MIC of FK-037 for 90% of Streptococcus pneumoniae was 0.5 mg/L. Haemophilus influenzae and Moraxella catarrhalis were inhibited by ≤2 mg/L FK-037.


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