Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Voorn, G. P.
Right arrow Articles by Michel, M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Voorn, G. P.
Right arrow Articles by Michel, M. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1994) 33, 785-794
© 1994 The British Society for Antimicrobial Chemotherapy

other

Efficacy of ciprofloxacin in treatment and prophylaxis of experimental Staphylococcus aureus endocarditis caused by a cloxacillin-tolerant strain and its non-tolerant variant

G. P. Voorna, J. Thompsona,*, W. H. F. Goessensb, W. C. Schmal-Bauera, P. H. M. Broedersa and M. F. Michelb

aDepartment of Infectious Diseases, University Hospital Leiden bDepartment of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, The Netherlands

Received 8 June 1993; accepted 16 November 1993

*Corresponding author: Dr J. Thompson, Department of Infectious Diseases, University Hospital, Building 1, C5-P, PO 9600, NL-2300, 2300 RC Leiden, The Netherlands

The efficacy of ciprofloxacin in treatment and prophylaxis of Staphylococcus aureus endocarditis in rats infected with a strain tolerant to the standard anti-staphylo-coccal antibiotics cloxacillin, vancomycin and teicoplanin was compared with its non-tolerant variant. After 5 days of treatment with ciprofloxacin 30 mg/kg subcuta-neously every 8 h bacterial densities in vegetations from animals infected with the tolerant and the non-tolerant strain were similar. Resistance to ciprofloxacin did not emerge in either strain of S. aureus during treatment.

In prophylaxis experiments a single dose of ciprofloxacin (30 mg/kg) administered 30 min before bacterial challenge afforded almost full protection for both the tolerant and the non-tolerant strain. At a lower dose of 6 mg/kg the protective effect was less compared with the higher dose, but no difference in the proportion of sterile vegetations was found between the two strains. Thus tolerance influenced neither treatment nor prophylaxis with ciprofloxacin. For strains of S. aureus tolerant to the usual anti-staphylococcal antibiotics ciprofloxacin could be a useful alternative for the treatment of infections.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
V. Sakka, L. Galani, A. Pefanis, D. Iliopoulos, G. Athanasopoulos, I. Donta, and H. Giamarellou
Successful moxifloxacin prophylaxis against experimental streptococcal aortic valve endocarditis
J. Antimicrob. Chemother., December 1, 2005; 56(6): 1160 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
I. Katsarolis, A. Pefanis, D. Iliopoulos, P. Siaperas, P. Karayiannakos, and H. Giamarellou
Successful Trovafloxacin Prophylaxis against Experimental Streptococcal Aortic Valve Endocarditis
Antimicrob. Agents Chemother., September 1, 2000; 44(9): 2564 - 2566.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.