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Journal of Antimicrobial Chemotherapy (1994) 33, 747-755
© 1994 The British Society for Antimicrobial Chemotherapy

other

In-vitro synergy between aminoglycosides deployed against Staphylococcus spp. harbouring a 6'-aminoglycoside acetyltransferase, 2''-aminoglycoside phosphotransferase enzyme

E. Culebras, J. C. Perez-Diaz, J. Blazquez, R. Alonso and F. Baquero

Departamento de Microbiologia, Hospital Ramóny Cajal Carretera de Colmenar Km 9,100, 28034 Madrid, Spain

Received 11 January 1993; accepted 1 November 1993

In-vitro synergistic effects between commercial aminoglycosides are described for gentamicin resistant Staphylococcus strains harbouring 6'-aminoglycoside acetyltransferase activity. Seventy eight strains were studied using the double-disc test and synergy was observed with combinations in which at least one of the components has a garosamine-like 6'-aminosugar. These results were confirmed in chequerboard titrations ({Sigma}FIC ≤ 0•5) carried out on Staphylococcus epidermidis strains RYC13036 and RYC4904. Additionally, a clear reduction in tobramycin acetylating activity was observed in the presence of gentamicin or netilmicin in crude extracts of these strains. These experiments suggest that the observed synergy is due to inhibition of the aminoglycoside-modifying enzyme by aminoglycosides with a garosamine like 6'-aminosugar component.


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