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Journal of Antimicrobial Chemotherapy (1994) 33, 231-242
© 1994 The British Society for Antimicrobial Chemotherapy

research-article

Kinetics and tolerability of intravitreal pefloxacin in rabbits

I. Cochereau-Massina, S. Marrakchi-Benjaafara, J. Baucheta, J. M. Valloisa, F. Faurissona, F. D'Hermiesb and J. J. Pocidaloa

a Institut National de la Santé et de la Recherche Médicale Unité 13, 190 Boulevard MacDonald, Paris 75 019 b Laboratoire d'Ophtalmologie, Hôpital Hôtel-Dieu Paris, France

Received 5 October 1992; accepted 10 September 1993

In the treatment of patients with bacterial endophthalmitis, the intravitreal administration of antibiotics is suitable for induction therapy since it provides immediate high concentrations in the vitreous humor. Pefloxacin has been shown to have good intraocular penetration when given systemically. In order to extend the potential routes of administration of this agent, we have assessed the kinetics and toxicity of pefloxacin in rabbit phakic eyes following intravitreal instillation. Kinetic parameters were determined for 12 albino and 12 pigmented rabbits after a single injection of 80 µg. Pefloxacin was undetectable in the aqueous humor but high concentrations were found in the chorioretina. The vitreal half-life was short (3 h). These results were consistent with posterior elimination via the chorioretina. Pefloxacin concentrations in the iris and chorioretina of pigmented rabbits were twofold greater than those in albino rabbits, probably because of binding to the pigmentary apparatus. Toxicity studies, including ophthalmological and histopatho-logical investigations, identified a maximum non-toxic dosage of 400 µg. Intravitreal pefloxacin may therefore be suitable for induction therapy in patients with endophthalmitis, although further studies in primates are required to confirm the efficacy and tolerability of this route of administration.


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