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Journal of Antimicrobial Chemotherapy (1993) 31, 29-38
© 1993 The British Society for Antimicrobial Chemotherapy

research-article

Comparative susceptibility profile of piperacillin/tazobactam against anaerobic bacteria

P. C. Appelbaum

Department of Pathology (Clinical Microbiology), Hershey Medical Center P.O. Box 850, Hershey, PA 17033, USA

Current data are summarized on the comparative susceptibility of Gram-positive and Gram-negative anaerobic bacteria to piperacillin/tazobactam and other anti-anaerobe agents. For β-lactamase-positive organisms, tazobactam, in fixed concentration or fixed ratio, lowered the MIC of piperacillin at least four-fold to susceptible levels in almost all cases; β-lactamase-negative strains were all susceptible to piperacillin alone. Susceptibility rates and MIC90, values for piperacillin/tazobactam were comparable to those of other anti-anaerobe agents, including other combinations of β-lactam agents with β-lactamase inhibitors, such as amoxycillin/clavulanate, ticarcillin/clavulanate, ampicillin/sulbactam and cefoperazone/sulbactam. Kinetic studies revealed IC50 and K1, values for tazobactam that were in most cases lower than those of clavulanate and sulbactam against β-lactamase-positive Gram-negative anaerobic bacilli.


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