Journal of Antimicrobial Chemotherapy (1993) 31, 949-961
© 1993 The British Society for Antimicrobial Chemotherapy
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Loracarbef versus doxycycline in the treatment of acute bacterial maxillary sinusitis
Received 10 March 1992; accepted 11 January 1993
*Correspondence to: Prof. C. E. Nord, Department of Microbiology, Karolinska Institute, Huddinge University Hospital, S-l41 86 Huddinge, Sweden
In a double-blind, multicentre study, 662 patients with acute maxillary sinusitis were randomly assigned to receive either loracarbef 400 mg bd (332 patients) or doxycycine, 200 mg for the first dose followed by 100 mg od, (330 patients) for ten days. One hundred and sixty-eight patients in the loracarbef group and 164 in the doxycycline group were evaluable for efficacy. Streptococcus pneumoniae and/or Haemophilus influenzae were isolated from approximately 75% of patients. The clinical response rate (cure or improvement) was significantly higher for patients receiving loracarbef (98·2%) than for those who received doxycycline (92·2%). There was no significant difference between the two groups with respect to bacteriological outcome, although more of the pre-treatment isolates were resistant to doxycycline (35 strains) than to loracarbef (five strains). Adverse events related to the gastrointestinal tract occurred in 11·7% and 10·6% of loracarbef- and doxycycline-treated patients respectively; therapy was terminated prematurely in ten patients in the loracarbef group and in nine in the doxycycline group. The results indicate that loracarbef is effective and safe treatment for acute maxillary sinusitis.
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