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Journal of Antimicrobial Chemotherapy (1993) 31, 901-908
© 1993 The British Society for Antimicrobial Chemotherapy

other

Influence of methylprednisolone on the intracellular antimicrobial activity of erythromycin and clindamycin against Legionella pneumophila

Futoshi Higa, Atsushi Saito, Jun Inadome, Nobuchika Kusano and Keizo Kitsukawa

First Department of Internal Medicine, School of Medicine, University of the Ryukyus 207 Uehara, Nishihara, Okinawa 903-01, Japan

Received 18 February 1992; accepted 5 February 1993

We have investigated the effect of methylprednisolone on the intracellular activity of erythromycin and clindamycin in vitro. An assay system was developed for the determination of intracellular activity of antibiotics against Legionella pneumophila using guinea pig resident alveolar macrophages. Erythromycin at a concentration of 0·625 mg/L (5 x MIC) and clindamycin at a concentration of 8 mg/L (MIC) inhibited the growth of a single strain of L. pneumophila in macrophages, whilst ceftizoxime at a concentration of 0·625 mg/L (5 x MIC) did not. Methylprednisolone at therapeutic concentrations did not affect the intracellular antibacterial activity of either erythromycin or clindamycin against L. pneumophila. We found no direct effect of methylprednisolone on the intracellular antibacterial activity of either erythomycin or cindamycin.


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