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Journal of Antimicrobial Chemotherapy (1993) 31, 893-900
© 1993 The British Society for Antimicrobial Chemotherapy

other

Methods for testing the susceptibility of anaerobic bacteria to two fluoroquinolone compounds, PD 131628 and clinafloxacin

A. L. Barrya, P. C. Fuchsb, D. M. Citronc, S. D. Allend and H. M. Wexlere

aThe Clinical Microbiology Institute PO Box 947, Tualatin, Oregon 97062 bSt Vincent Hospital and Medical Center Portland, Oregon 97225 cR.M. Alden Research Laboratory Santa Monica, California 90404 dIndiana University Medical Center Indianapolis, Indiana 46202 eV.A. Wadsworth Medical Center, Los Angeles California 90073, USA

Received 23 September 1992; accepted 8 February 1993

The susceptibility of anaerobic bacteria to two new fluoroquinolones, PD 131628 (the bioactive form of PD 131112 or CI-990) and clinafloxacin (CI-960 or PD 127391), was determined with the agar dilution procedures and two media, and one broth microdilution procedure. Sparfioxacin and ciprofloxacin were also tested by the broth microdilution method. One hundred anaerobic isolates and four control strains were tested by the three methods which gave minimum inhibitory concentrations (MICs) that were essentially comparable, but not identical. With the broth microdilution method, the relative potency of the four fluoroquinolones was: clinafioxacin > PD 131628 > sparfioxacin > ciprofloxacin. For the latter three drugs but not clinafloxacin, the MIC values were often near the proposed interpretive breakpoint concentrations, and thus minor methodological differences frequently influenced the interpretive categories. Replicate agar dilution tests in five laboratories established MIC control limits for each of four control strains: those MIC limits could also be used to define the expected performance of the two alternative methods.


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