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Journal of Antimicrobial Chemotherapy (1993) 31, 581-584
© 1993 The British Society for Antimicrobial Chemotherapy

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Tissue penetration of clindamycin in diabetic foot infections

Charles Duckwortha, John F. Fishera,*, Sally A. Cartera, Cheryl L. Newmana, Cindy Cogburna, Robert R. Nesbitb and Charles H. Wrayb

aDepartments of Medicine Augusta, Georgia 30912, USA bDepartments of Surgery, Medical College of Georgia Augusta, Georgia 30912, USA

Received 27 February 1992; accepted 23 November 1992

Corresponding author

Serum and tissue samples were obtained during surgery from four diabetics with neuropathy who underwent debridement or amputation for foot infections while receiving cindamycin 600 or 900 mg iv. Clindamycin concentrations were assayed by radioimmunoassay. Clindamycin was detected in all serum and tissue samples (range: 0·04–2·8 mg/kg in tissues and 1·1–11·1 mg/L in serum). In nine of the eleven tissue samples the clindamycin concentration exceeded the MICs reported for many pathogens commonly involved in such infections. In only a single instance was the ratio of tissue to serum concentration < 0·13.


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