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Journal of Antimicrobial Chemotherapy (1993) 31, 497-504
© 1993 The British Society for Antimicrobial Chemotherapy

other

The in-vitro activity of OPC-17116, a new 5-methyl substituted quinolone

R. Wise, J. M. Andrews and N. Brenwald

Department of Microbiology, Dudley Road Hospital Birmingham B18 7QH, UK

Received 23 July 1992; accepted 4 December 1992

The in-vitro activity of the new 5-methylated fluoroquinolone OPC-17116 was compared with that of other fluoroquinolines and ß-lactams against a total of 690 bacterial strains. With the exception of Kiebsiella and Serratia spp., 90% of the Enterobacteriaceae were inhibited by 0·25 mg/L. OPC-17116 inhibited 90% of Serratia spp. at 8 mg/L and Klebsiella spp. at 4 mg/L. Moraxella catarrhalis and Haemophilus influenzae were highly susceptible (MIC90≤0·03 mg/L). Pseudomonas aeruginosa were more susceptible to ciprofloxacin (MIC90≤0·25 mg/L) than OPC-17116 (MIC90 1 mg/L). Generally, OPC-17116 was more active than cipro floxacin against Gram-positive cocci, 90% of Staphylococcus spp. being inhibited by ≤0·25 mg/L. OPC-17116 displayed greater activity than ciprofloxacin against Chiamydia spp. (MICs≤0.12 and ≤2 mg/L, respectively).


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