Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Zhou, X. Y.
Right arrow Articles by Gutmann, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, X. Y.
Right arrow Articles by Gutmann, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1993) 31, 473-480
© 1993 The British Society for Antimicrobial Chemotherapy

other

Activity of the ß-lactamase inhibitor BRL 42715 against cephalosporinases produced by Enterobacteriaceae

X. Y. Zhoua, M. D. Kitzisb, J. F. Acara,b and L. Gutmanna,c,*

aLaboratoire de Microbiologie Médicale, Université Paris VI 15 rue de l'Ecole de Médicine, 75270 Paris Cedex 06, France bLaboratoire de Microbiologie, Hôpital Saint-Joseph 7 rue Pierre-Larousse, 75674 Paris Cedex 14, France cLaboratoire de Microbiologie, Hôpitai Broussais 96 rue Didot, 75014 Paris, France

Received 18 June 1992; accepted 26 November 1992

*Corresponding author

BRL 42715, a novel ß-lactamase inhibitor, was evaluated for its capacity to inhibit cephalosporinases. BRL 42715 was effective in potentiating the activity of antibiotics against clinical isolates of Enterobacteriaceae that produced high levels of cephalo sporinases. This correlated well with the very low 5O% inhibition values (<0–004 mg/L) of BRL 42715 for cephalosporinases extracted from different species. When compared in vitro to clavulanic acid, sulbactam, and tazobactam, BRL 42715 was the most efficient inhibitor of cephalosporinase.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.