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Journal of Antimicrobial Chemotherapy (1992) 30, 833-838
© 1992 The British Society for Antimicrobial Chemotherapy

research-article

In-vivo activity of streptomycin and clofazimine against established infections of Mycobacterium avium complex in beige mice

Pattisapu R. J. Gangadharam* and Kishori Parikh* *

Mycobacteriology Research, Division of Infectious Diseases, University of Illinois College of Medicine Chicago, Illinois 60612, USA

Received 2 August 1991; returned 14 July 1992; accepted 14 July 1992

*Correspondence to: Prof. P. R. J. Gangadharam, Microbiology and Pathology and Director of Mycobacteriology Research, University of Illinois College of Medicine at Chicago, 835 S. Wolcott Avenue, Room E709 (M/C 790). Chicago, Illinois 60612, USA

Beige mice were challenged with 106–107 cfu of Mycobacterium avium intracellulare strain 101 and 22 days later treated with streptomycin 150 mg/kg/day alone, clofazimine 20 mg/kg/day alone, streptomycin 150 mg/kg/day plus clofazimine 20 mg/kg/day, or no antimicrobial agent (untreated controls). Both single-drug therapies partially reduced the cfu counts in spleen, liver and lungs compared with the controls however the combination was significantly more effective and completely eliminated the pathogen from the spleen and lungs of some animals after eight weeks treatment.


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V. M. Reddy, J. F. O' Sullivan, and P. R. J. Gangadharam
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