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Journal of Antimicrobial Chemotherapy (1992) 30, 745-751
© 1992 The British Society for Antimicrobial Chemotherapy

review-article

Malignant otitis externa: the therapeutic evolution of a lethal infection

Helen Glamarellou

1st Department Propedeutic Medicine, Athens Univeristy School of Medicine, Laiko General Hospital GR 115 27 Athens, Greece

Received 20 January 1992; accepted 22 April 1992

Malignant otitis externa (MOE) is a potentially fatal infection of the external auditory canal caused by Pseudomonas aeruginosa in a majority of cases. Treatment of MOE has changed over the years. Surgical debridement of all infected tissue is no longer considered the treatment of choice and has been replaced by localized surgical debridement supplemented with long-term antimicrobial chemotherapy. The recent availability of the fluroquinolones and in particular ciprofloxacin has opened up new therapeutic opportunities.


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