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Journal of Antimicrobial Chemotherapy (1992) 30, 463-474
© 1992 The British Society for Antimicrobial Chemotherapy

research-article

Characterization of antibiotic-resistant Corynebacterium striatum strains

Marilyn C. Robertsa,*, Rebecca B. Leonardb, Ann Briseldenb, Fritz D. Schoenknechtb,c and Marie B. Coyleb,c

aDepartments of Pathobiology, University of Washington Seattle, Washington 98195, USA bDepartments of Laboratory Medicine, University of Washington Seattle, Washington 98195, USA cDepartments of Microbiology, University of Washington Seattle, Washington 98195, USA

Received 14 January 1992; returned 13 May 1992; accepted 13 May 1992

*Corresponding author

Antibiotic-resistant Corynebacterium striatum strains were isolated from 14 Harborview and one Veterans Administration Hospital patients in Seattle during the period 1987–90. These clindamycin-erythromycin resistant strains were shown to hybridize with the ermCd gene, which was cloned from a Corynebacterium diph-theriae plasmid and encodes for a rRNA methylase. Thirteen of these strains also hybridized with the tetM gene probes, and were tetracycline resistant The ermCd gene could be transferred, by conjugation, while the tetM gene was not transferable.


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