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Journal of Antimicrobial Chemotherapy (1992) 30, 39-46
© 1992 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of ten antimicrobial agents against penicillin-resistant Streptococcus pneumoniae

T.J. Neal, M. A. T. O'Donoghue, E.J. Ridgway and K.D. Allen1

Department of Medical Microbiology, Whiston Hospital Dragon Lane, Prescot, Merseyside L35 5DR, UK

Received 3 September 1991; returned 12 February 1992; accepted 12 February 1992

*Correspondence to: Dr K. D. Allen. Consultant Microbiologist, Whiston Hospital. Dragon Lane, Prescot, Merseyside L35 5DR, UK.

The minimum inhibitory concentrations (MICs) of ten antibiotics were determined by the agar dilution method for 40 strains of penicillin-resistant Streptococcus pneumoniae, all of which were clinical isolates from this laboratory. The antibiotics tested were clarithromycin, erythromycin, teicoplanin, vancomycin, ceftriaxone, cefodizime, azithromycin, ramoplanin, ciprofloxacin and MDL 62873. Of these agents, clarithromycin, vancomycin, teicoplanin, ceftriaxone, ramoplanin and MDL 62873 were the most active. The role of these antibiotics as alternatives to penicillin for the treatment of infections caused by penicillin-resistant S. pneumoniae is discussed.


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