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Journal of Antimicrobial Chemotherapy (1977) 3, 579-584
© 1977 The British Society for Antimicrobial Chemotherapy

research-article

Studies on cinoxain

3. Concentrations of cinoxacin in serum, urine and tissues of urological patients

S. Colleen, K.-E. Andersson and P.-A. Mårdh

Department of Urology, University Hospital S-221 85 Lund, Sweden Department of Clinical Pharmacology, Institute of Pharmacology, University of Århus Dk-8000 Århus C, Denmark Institute of Medical Microbiology, University of Lund S-223 62 Lund, Sweden

accepted 5 April 1977

The concentrations of cinoxacin in body fluids and tissues of the urinary tract were studied during a dose interval in 13 patients given 500 mg of the drug twice daily. There was a wide variation in the peak serum concentrations (28 to 28 µg/ml, mean 16.9 µg/ml); the highest concentrations were generally reached within 3 h of administration. A mean peak concentration of 766 µg/ml was found in urine, and the mean cumulative urinary excretion during a 12-h interval was 65%. In bladder and prostatic tissue, the concentrations of cinoxacin were lower than in serum. The concentrations in renal tissue showed a considerable variation, but were generally higher than those in serum. No clear relation was found between the concentrations in serum and renal tissue.


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