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Journal of Antimicrobial Chemotherapy (1991) 27, 677-681
© 1991 The British Society for Antimicrobial Chemotherapy

research-article

Episodic acyclovir therapy to abort recurrent attacks of genital herpes simplex infection

J. D. Whatley and R. N. Thin

Department of Genitourinary Medicine, St. Thomas' Hospital London SE1 7 EH. UK

Received 23 October 1990; accepted 30 January 1991

Frequent recurrence of genital herpes simplex infection can be a distressing condition. Continuous suppressive oral acyclovir is effective but expensive. Hitherto episodic therapy has given disappointing results. An open comparative study of patient initiated therapy is reported here. Acyclovir 200 mg five times daily for five daysaborted 44% of recurrences and shortened 38% by 50%, giving useful response in 82% of 34 recurrences. Acyclovir 400 mg twice daily for five days aborted 60% and shortened 17% giving useful benefit in 77% of 20 recurrences. Acyclovir 200 mg twice a day for five days gave unsatisfactory results. Patients were selected for frequent recurrences and a recognized prodrome, and care was taken to help toidentify early prodromal symptoms. In these patients acyclovir in dosages of 200 mg five times daily for five days and 400 mg bd for five days proved convenient and cost effective.


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Home page
 Sex. Transm. Infect.Home page
A Strand, R Patel, H C Wulf, and K M Coates
Aborted genital herpes simplex virus lesions: findings from a randomised controlled trial with valaciclovir
Sex Transm Inf, December 1, 2002; 78(6): 435 - 439.
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