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Journal of Antimicrobial Chemotherapy (1991) 27, 655-662
© 1991 The British Society for Antimicrobial Chemotherapy

research-article

Pharmacokinetic study of lomefloxacin and its effect on the faecal flora of volunteers

D. A. Leigh, C. Harris, S. Tait, B. Walsh and P. Hancock

Department of Microbiology, Wycombe General Hospital High Wycombe, Bucks HP11 2TT, UK

Received 5 October 1990; accepted 25 January 1991

In a volunteer pharmacokinetic study mean peak serum concentrations of lomefloxacin of 7.19mg/l were obtained 1.5 h after an oral dose of 400 mg. Women had higher concentrations than men. Urinary excretion was 34% in 6 h and 63% in 24 h and the mean peak concentration was 699 mg/l. Saliva concentrations were 37% of those in serum. Lomefloxacin was detectable in the faeces up to seven days after the last dose.

The major effect of lomefloxacin on the faecal flora of volunteers following a four day course of 400 mg once daily was the elimination of strains of Enterobacteriaceae and an increase in the numbers of Gram-positive cocci, mainly streptococci. There was no effect on anaerobic bacteria or yeasts. Lomefloxacin was well tolerated and no side effects were recorded. No bacterial resistance was detected after treatment.


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