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Journal of Antimicrobial Chemotherapy (1991) 27, 647-654
© 1991 The British Society for Antimicrobial Chemotherapy

research-article

Reappraisal of amoxycillin absorption kinetics

J. F. Westphala, A. Deslandesb, J. M. Brogarda and C. Carbonc

aDépartement de Médecine Interne, Clinique Médicale B, Centre Hospitalo-Universitaire 1 Place de l'Hôpital 67091 Strasbourg Cedex bLaboratoire de Pharmacocinetique, Faculte de Médecine Rue J. B. Clément, 92290 Chatenay-Malabry aLaboratoire d'Etude des Infections Expérimentales et des Traitements Anti-infectieux-Inserm UI3 UER Xavier-Bichat, 75018 Paris, France

Received 6 July 1990; accepted 24 January 1991

Interest in the intestinal absorption mechanisms of drugs has increased because transepithelial passage across the gut does not necessarily follow a passive diffusion process. Amoxycillin, like other amino-ß-lactamantibiotics, has been demonstrated in vitro to use the dipeptide carrier-mediated system in rodent small intestine. In order to assess the in-vivo relevance of these data, we applied the Loo-Riegelman methodfor a reappraisal of amoxycillin absorption kinetics in healthy human volunteers. The results showed evidence ofa saturable carrier-mediated uptake of this antibiotic. With respect to the in-vitro data previously published, the dipeptide carrier system would appear to be the most likely transport mechanism.


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