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Journal of Antimicrobial Chemotherapy (1991) 27, 577-587
© 1991 The British Society for Antimicrobial Chemotherapy

research-article

Effects of carbon dioxide and sub-lethal levels of antibiotics on adherence of coagulase-negativestaphylococci to polystyrene and silicone rubber

M. H. Wilcoxa,*, R. G. Fincha,b, D. G. E. Smithc, P. Williamsc and S. P. Denyerc

aDepartment of Microbial Diseases, The City Hospital Nottingham bDepartments of Microbiology, University of Nottingham NG7 2UH, UK cPharmaceutical Sciences, University of Nottingham NG7 2UH, UK

Received 26 September 1990; accepted 11 January 1991

*Corresponding author: Department of Experimental & Clinical Microbiology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK

Fifty coagulase-negative staphylococci (CNS) strains were investigated for adherence to both silicone rubber and polystyrene using a microtitre tray system. Culture in an atmosphere containing a physiological level of carbon dioxide (5% CO2) profoundly affected adherent growth to both surfaces. Most strains adhered less well in this atmosphere compared to in air alone, with mean reductions in adherence of 84% and 86% to silicone rubber and polystyrene respectively. Occasional strains adhered better in 5% CO2. The effects of antibiotic concentrations equivalent to 1/4 MIC of cefuroxime, ciprofloxacin, vancomycin and teicoplanin on the adherence of 10 CNS strains were also studied. Vancomycin and teicoplanin frequently increased adherence to silicone rubber and polystyrene compared to controls. The effects of antibiotics on adherence were not only strain dependent but also sometimes atmosphere or surface specific. Antibiotic-induced changes in adherence did not appear to correlate with changes in strain protein profiles or surface hydrophobicities.


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