Journal of Antimicrobial Chemotherapy (1991) 27, 569-575
© 1991 The British Society for Antimicrobial Chemotherapy
research-article |
Factors determining resistance to ß-lactam combined with ß-lactamase inhibitors in Escherichia coli
aServicio de Microbiologia, Hospital Ramón y Cajal 28034 Madrid bInstituto de Investigationes Biomédicas CSIC 28029 Madrid, Spain
Received 16 August 1990; accepted 25 January 1990
*Corresponding author
The influence of inoculum size, ß-lactamase hyperproduction (multicopy plasmid) and modifications in the outer membrane protein profile on the susceptibility of Escherichia coli to combinations of amoxycillin/clavulanate, amoxycillin/sulbactam, amoxycillin/tazobactam and piperacillin/tazobactam were studied. For all combinations the bacterial susceptibility was affected by factors determining an increase in ß-lactamase (inoculum size or hyperproduction). Clavulanic acid was the most efficient ß-lactamase inhibitor. The absence of the outer membrane proteins, OmpF and OmpC, did not significantly affect susceptibility to the combinations per se but when combined with the presence of ß-lactamase high MICs were observed. Seven out of eight amoxycillin/clavulanate resistant clinical isolates of E. coli had ß-lactamase hyperproduction and a decrease or absence of OmpF.
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