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Journal of Antimicrobial Chemotherapy (1990) 25, 237-245
© 1990 The British Society for Antimicrobial Chemotherapy

research-article

Antimycotic effects of octenidine and pirtenidine

M. A. Ghannouma, K. Abu Elteena, M. Ellabibb and P. A. Whittakerb,

aDepartment of Botany and Microbiology, Kuwait University Kuwait bDepartment of Biology, Maynooth College Maynooth, Ireland

Received 7 April 1989; accepted 15 August 1989

Correspondence: Professor P. A. Whittaker

The effects of octenidine and pirtenidine on yeasts (in particular Candida albicans) have been studied. MIC and MCC values have been established as well as the inhibitory effects on growth, budding and germ tube formation. The drugs were shown to cause extensive leakage of cytoplasmic contents from the cells which was correlated with morphological and ultrastructural changes in the yeast.


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