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Journal of Antimicrobial Chemotherapy (1990) 25, 227-236
© 1990 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of SCH39304 in comparison with amphotericin B and flaconazole

F. Meunier, C. Lambert and P. Van der Auwera

Service de Médecine et Laboratoire d'Investigation Clinique H. J. Tagnon, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles rue Héger-Bordet 1, 1000 Brussels, Belgium

Received 27 February 1989; accepted 25 September 1989

The in-vitro activity of SCH39304, a new imidazolc, was compared with that of amphotericin B using two media (Sabouraud dextrose and tissue culture (TC) medium) with or without 25% human serum. At an inoculum of 1·5 x 104 cfu/ml, the IC95% for amphotericin B ranged from 0·08 to 0·3 mg/l irrespective of the medium. At the same inoculum, the IC95% of the two imidazoles ranged from 0·3 to > 80 mg/l. The inoculum effect (from 1·5 x 104 to 1·5 x 105 cfu/ml) was < 1 dilution for the three antifungal agents. Serum increased the inhibitory activity (IC80%) of SCH393O4 and fluconazole but not of amphotericin B. The IC80%, IC95% and minimal fungicidal concentration (MFC) for amphotericin B usually ranged within two dilutions. Using kill curve methodology, the initial killing rate (0–4 h) of amphotericin B correlated with concentration (P < 0·001), and was faster in TC medium than in Sabouraud dextrose (P < 0·0006). SCH393O4 and fluconazole did not produce any significant killing over the range of concentrations tested (0·5–20 mg/l). SCH393O4 was similar to fluconazole.


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