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Journal of Antimicrobial Chemotherapy (1990) 25, 209-216
© 1990 The British Society for Antimicrobial Chemotherapy

research-article

Comparison of four methods for the determination of MIC and MBC of penicillin for viridans streptococci and the implications for penicillin tolerance

Peter A. James

Joint PHLS/DHA Microbiology Department, Royal United Hospital Combe Park, Bath BA1 3NG, UK

Received 10 March 1989; accepted 4 September 1989

Four methods of MIC and MBC determination were examined to compare their reproducibility and ability to detect penicillin tolerance. The MIC and MBC of penicillin were determined for 28 strains of viridans streptococci by a microdilution method, a macrodilution method, a membrane method, and a gradient-plate method using a spiral-plating device. The macrodilution, membrane and gradient plate methods were found to be acceptable for MIC determination with a reproducibility to within one doubling dilution, but only the gradient method gave acceptable reproducibility for MBC determinations. The consequence of these findings with respect to penicillin tolerance is discussed.


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