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Journal of Antimicrobial Chemotherapy (1989) 23, 267-273
© 1989 The British Society for Antimicrobial Chemotherapy

research-article

Treatment of acute uncomplicated urinary tract infections with single daily doses of cefuroxime axetil

D. A. Leigh, G. E. Joy, S. Tait, K. Harris and B. Walsh

Department of Microbiology, Wycombe General Hospital High Wycombe, Bucks, UK

Received 29 July 1988; accepted 12 October 1988

Cefuroxime axetil in a single daily dose of 250 mg for ten days was given to 75 women with symptoms of acute uncomplicated urinary tract infections. Fifty-nine women were found to have significant bacteriuria but one was excluded as urethral catheterization was required. The dose was taken at night with a milky drink. Ninety-five per cent of women had a clear urine during treatment. Compliance studies showed that antimicrobial activity was detectable in early morning urines up to 8–10 h after the dose. Post treatment, 93% of women were clear of their original infecting organism but five women had become reinfected with a different strain of Escherichia coli. At the six week follow up 98% of women were still clear although one further reinfection had occurred. The overall cure rate was 86%, including 11% reinfection. Adverse events developed in 17 (23%) of the 75 women with candida vaginitis (8) and diarrhoea (4) being most common. Cefuroxime axetil is a valuable therapy for the treatment of urinary tract infection particularly when due to ß-lactamase producing bacteria.


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