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Journal of Antimicrobial Chemotherapy (1989) 23, 247-251
© 1989 The British Society for Antimicrobial Chemotherapy

research-article

The effect of ciprofloxacin and pefloxacin on bone marrow engraftment in the spleen of mice

Eli Somekh, Boaz Lev, Eli Schwartz, Asher Barzilai and Ethan Rubinstein

Infectious Diseases Unit, Chaim Sheba Medical Center and Department of Pediatrics, Edith Wolfson Hospital Israel

Received 20 June 1988; accepted 4 October 1988

Correspondence to: Dr Ethan Rubinstein, Unit of Infectious Diseases, Chaim Sheba Medical Ctr., Tel-Hashomer 52621, Israel

In order to investigate the in-vivo effect of ciprofloxacin and pefloxacin on bone marrow engraftment in mice, irradiated mice were transplanted with bone marrow graft (5 x 105 cells/mouse) obtained from syngeneic mice. Three groups of mice (30 mice in each) received a bone marrow graft incubated for 1 h with ciprofloxacin at concentrations of 0·5, 5 and 50 mg/l. Six additional groups (30 mice in each) were treated twice daily after transplantation with intra-peritoneal injections of ciprofloxacin in dosages of 25, 50 and 100 mg/kg/24 h or pefloxacin in dosages of 10 and 100 mg/kg/24 h. Evaluation of bone marrow engraftment was performed in animals injected with I125 Iodo-deoxyuridine (0·5µCi/mouse) by radioactive counting of the entire spleen and also by counting visible colonies on the spleen surface. The results of this study demonstrate a statistically significant depression of bone marrow graft uptake (P<0·05, student t-test) in mice treated twice daily with ciprofloxacin in dosage of 100 mg/kg/24 h, a concentration far beyond the therapeutic range.


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