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Journal of Antimicrobial Chemotherapy (1989) 23, 237-245
© 1989 The British Society for Antimicrobial Chemotherapy

research-article

Echinococcus multilocularis metacestodes: biochemical and ultrastructural investigations on the effect of isatin (2-3 indoline dione) in vivo

Isabelle Delabre-Defayollea, Marie-Elisabeth Sarcirona, Patrick Audina, Claude Gabrionb, Thérèse Duriezc, Joëile Parisa and Anne-Françoise Petavya

aLaboratoire de Parasitologie et de Chimie Thérapeutique-U.C.B. 8 Avenue Rockefeller-69373 Lyon, Cedex 08 bLaboratoire de Parasitologie Camparée U.S.T.L.-Place E. Bataillon-34000 Montpellier cLaboratoire de Parasitologie, Faculté de Pharmacie rue Laguesse 59000 Lille, France

Received 20 July 1988; accepted 9 September 1988

A study on the biochemical and ultrastructural effects of isatin on Echinococcus multilocularis metacestodes in Meriones unguiculatus is reported. In the metacestode, after an 18 day treatment period, the alkaline phosphatase and lactate dehydrogenase activities decreased and the acid phosphatase activity increased. Glucose and glycogen stores declined significantly. Examinations of the ultrastructure revealed an increase of lysosomes and phagocytic reactions. The protoscolesces were damaged and an abnormal striated process appeared. The tegumental cytoplasmic syncytium remained unaltered. These observations suggest that isatin derivatives may have a role in the chemotherapy of infections caused by Echinococcus spp.


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