Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Van der Auwera, P.
Right arrow Articles by Pierard, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van der Auwera, P.
Right arrow Articles by Pierard, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1989) 23, 209-219
© 1989 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of lomefloxacin in comparison with pefloxacin and ofloxacin

P. Van der Auweraa, P. Greniera, Y. Glupczynskib and D. Pierardc

aService de Médecine et Laboratoire d'Investigation Clinique H. J. Tagnon, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles rue Héger-Bordet, 1, B-1000, Bruxelles bLaboratoire de Microbiologie, Fondation Reine Elisabeth, Hôpital Universitaire Brugmann Bruxelles cLaboratoire de Microbiologie, Akademisch Ziekenhuis, Vrije Universiteit Brussel Bruxelles, Belgium

Received 12 August 1988; accepted 12 October 1988

The in-vitro activity of lomefloxacin (SC 47111, NY-198) was investigated by the determination of MICs in agar and in broth, of MBCs in broth, of killing curves and of the duration of the post-antibiotic effect. MICs measured in broth and in agar were almost identical. Lomefloxacin was two- to eight-fold less active against Grain-positive bacteria than ofloxacin. Its activity against Staphylococcus aureus was independent of resistance to penicillin and oxacillin. The activity of lomefloxacin, ofloxacin and pefloxacin was poor against JK corynebacteria. Enterobacteriaceac, Aeromonas spp., Haemophilus influenzae, Neisseriaceac and Campylobacter jejuni were highly susceptible to the three quinolones investigated. Non-fermenting Gram-negative bacilli were less susceptible. MBCs were within one dilution of the corresponding MICa. The killing rate was very high against Gram- negative bacilli (2·5–4·0 log cfu/ml reduction in 2 h) whereas it was low against Gram-positive bacteria (0·5–1·0 log cfu/ml reduction in 2 h). Emergence of resistance was not observed. The duration of the post-antibiotic effect with Gram- negative bacilli depended on the strain and species (median: 0·9–1·5 h). The post-antibiotic effect was insignificant with Staph. aureus.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.