Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (79)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Gordon, C. A.
Right arrow Articles by Marriott, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gordon, C. A.
Right arrow Articles by Marriott, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1988) 22, 667-674
© 1988 The British Society for Antimicrobial Chemotherapy

research-article

Antibiotic interaction and diffusion through alginate and exopolysaccharide of cystic fibrosis-derived Pseudomonas aeruginosa

C. A. Gordon, N. A. Hodges and C. Marriott

Department of Pharmacy, Brighton Polytechnic Moulsecoomb, Brighton BN2 4GJ, UK

Received 3 March 1988; returned 29 June 1988; accepted 29 June 1988

The interaction of five anti-pseudomonas antibiotics with both commercial and pseudomonas alginates was studied by investigation of their binding and diffusion characteristics. The two sources of alginate were qualitatively but not quantitatively similar in these respects. Unlike the ß-lactams, gentamicin and tobramycin bound avidly to both sources of alginate and, when the alginate gel to antibiotic ratio was high, the aminoglycosides exhibited diffusion coefficients which were approximately 20% of the ß-lactam values. At much lower ratios of alginate to antibiotic the aminoglycosides caused precipitation in the alginate with apparent disruption of the gel structure, and ultimately penentrated the gel at a faster rate than the ß-lactams. The strong aminoglycoside binding to alginate was reduced, but not eliminated by the presence of physiological concentrations of salts.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
C. Sandt, J. Barbeau, M.-A. Gagnon, and M. Lafleur
Role of the ammonium group in the diffusion of quaternary ammonium compounds in Streptococcus mutans biofilms
J. Antimicrob. Chemother., December 1, 2007; 60(6): 1281 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
M. Gualtieri, L. Bastide, P. Villain-Guillot, S. Michaux-Charachon, J. Latouche, and J.-P. Leonetti
In vitro activity of a new antibacterial rhodanine derivative against Staphylococcus epidermidis biofilms
J. Antimicrob. Chemother., October 1, 2006; 58(4): 778 - 783.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
D. Hill, B. Rose, A. Pajkos, M. Robinson, P. Bye, S. Bell, M. Elkins, B. Thompson, C. MacLeod, S. D. Aaron, et al.
Antibiotic Susceptibilities of Pseudomonas aeruginosa Isolates Derived from Patients with Cystic Fibrosis under Aerobic, Anaerobic, and Biofilm Conditions
J. Clin. Microbiol., October 1, 2005; 43(10): 5085 - 5090.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. A. Al-Fattani and L. J. Douglas
Penetration of Candida Biofilms by Antifungal Agents
Antimicrob. Agents Chemother., September 1, 2004; 48(9): 3291 - 3297.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
M. R. Parsek and C. Fuqua
Biofilms 2003: Emerging Themes and Challenges in Studies of Surface-Associated Microbial Life
J. Bacteriol., July 15, 2004; 186(14): 4427 - 4440.
[Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
N. Bagge, M. Schuster, M. Hentzer, O. Ciofu, M. Givskov, E. P. Greenberg, and N. Hoiby
Pseudomonas aeruginosa Biofilms Exposed to Imipenem Exhibit Changes in Global Gene Expression and {beta}-Lactamase and Alginate Production
Antimicrob. Agents Chemother., April 1, 2004; 48(4): 1175 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
W. Kim, T. Killam, V. Sood, and M. G. Surette
Swarm-Cell Differentiation in Salmonellaenterica Serovar Typhimurium Results in Elevated Resistance to Multiple Antibiotics
J. Bacteriol., May 15, 2003; 185(10): 3111 - 3117.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. C. Walters III, F. Roe, A. Bugnicourt, M. J. Franklin, and P. S. Stewart
Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and Tobramycin
Antimicrob. Agents Chemother., January 1, 2003; 47(1): 317 - 323.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
R. M. Donlan and J. W. Costerton
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
Clin. Microbiol. Rev., April 1, 2002; 15(2): 167 - 193.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
A. L. Spoering and K. Lewis
Biofilms and Planktonic Cells of Pseudomonas aeruginosa Have Similar Resistance to Killing by Antimicrobials
J. Bacteriol., December 1, 2001; 183(23): 6746 - 6751.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. W. Costerton, P. S. Stewart, and E. P. Greenberg
Bacterial Biofilms: A Common Cause of Persistent Infections
Science, May 21, 1999; 284(5418): 1318 - 1322.
[Abstract] [Full Text]

Home page
 ADRHome page
P. Gilbert, J. Das, and I. Foley
Biofilm Susceptibility to Antimicrobials
Advances in Dental Research, April 1, 1997; 11(1): 160 - 167.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.