Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hardy, D. J.
Right arrow Articles by Fernandes, P. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hardy, D. J.
Right arrow Articles by Fernandes, P. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1988) 22, 631-636
© 1988 The British Society for Antimicrobial Chemotherapy

research-article

Susceptibility of Campylobacter pylori to macrolides and fluoroquinolones

Dwight J. Hardy, Charles W. Hanson, Dena M. Hensey, Jill M. Beyer and Prabhavathi B. Fernandes

Anti-infective Research Department, Pharmaceutical Products Division, Abbott Laboratories Abbott Park, illinois 60064, USA

Received 25 April 1988; returned 3 July 1988; accepted 3 July 1988

The in-vitro activities of several 14-, 15- and 16-membered macrolides and fluoroquinolones against Campylobacter pylori were determined. In general, macrolides, such as clarithromycin and flurithromycin, were more active than the 15-membered macrolide, azithromycin, which was more active than 16-membered macrolides, such as miocamycin and rokitamycin. Fluoroquinolones, except ciprofloxacin and A-6l827, were less active than macrolides. Clarithromycin was the most active of the new compounds against C. pylori and was as active as ampicillin. MICs of all compounds at pH 5.5 were increased when compared to MICs determined at pH 7.3. All compounds had MBCs which were the same as or within one two-fold dilution of their MICs. Frequencies of spontaneous resistance development by C. pylori NCTC 11637 at four and eight times the MIC of the compounds were low and ranged from <1 x 10–9 to 1 x 10–7


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
H. Endo, H. Yoshida, N. Ohmi, and S. Higuchi
Effects of Lansoprazole and Amoxicillin on Uptake of [14C]Clarithromycin into Gastric Tissue in Rats
Antimicrob. Agents Chemother., December 1, 2001; 45(12): 3451 - 3455.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
H. Endo, H. Yoshida, N. Ohmi, and S. Higuchi
Effects of lansoprazole, clarithromycin and pH gradient on uptake of [14C]amoxycillin into rat gastric tissue
J. Antimicrob. Chemother., April 1, 2001; 47(4): 405 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
I. J. Hassan, R. M. Stark, J. Greenman, and M. R. Millar
Activities of beta -Lactams and Macrolides against Helicobacter pylori
Antimicrob. Agents Chemother., June 1, 1999; 43(6): 1387 - 1392.
[Abstract] [Full Text]

Home page
 Arch Intern MedHome page
J. A. Salcedo and F. Al-Kawas
Treatment of Helicobacter pylori Infection
Arch Intern Med, April 27, 1998; 158(8): 842 - 851.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
T. Alarcón, D. Domingo, M. López-Brea;, R. Piccolomini, and G. Di Bonaventura
Discrepancies between E-Test and Agar Dilution Methods for Testing Metronidazole Susceptibility of Helicobacter pylori
J. Clin. Microbiol., April 1, 1998; 36(4): 1165 - 1166.
[Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.