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Journal of Antimicrobial Chemotherapy (1988) 22, 605-612
© 1988 The British Society for Antimicrobial Chemotherapy

research-article

Effects of erythromycin base and erythromycin esters on protein synthesis in vivo in Escherichia coli

Siv G. E. Andersson and Charles G. Kurland

Department of Molecular Biology, Biomedical Center Box 590, S-751 24 Uppsala, Sweden

Received 25 March 1988; returned 7 June 1988; accepted 7 June 1988

The inhibitory effects on protein synthesis in vivo of erythromycin base and several erythromycin esters have been determined. An experimental method was used, especially suited for studies on short-lived antibiotics causing low levels of inhibition. Most of the tested derivatives were 2–3% as active as erythromycin base while a split product of erythromycin, anhydroerythromycin, was 4% as effective.


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