Journal of Antimicrobial Chemotherapy (1988) 22, 597-604
© 1988 The British Society for Antimicrobial Chemotherapy
research-article |
Distribution of ß-lactamases and phenotype analysis in clinical strains of Acinetobacter calcoaceticus
aDepartment of Microbiology, Bichat University-Hospital 46 Rue Huchard, 75877 Paris Cedex 18 bDepartment of Microbiology, Cochin Hospital Paris, France
Received 16 February 1988; returned 13 July 1988; accepted 13 July 1988
*Corresponding author
One hundred clinical strains of Acinetobacter calcoaceticus isolated from 1981 to 1986 were screened for enzymatic resistance to ß-lactam antibiotics. Fourteen ß-antibiotics were tested and four phenotypes were defined on the basis of enzymatic resistance and of susceptibility to the following ß-lactams: ticarcillin, piperacillin, cefotaxime, and ceftazidime. The resistance of A. calcoaceticus to ß-lactam antibiotics was predominantly due to ß-lactamases, which were produced by 81% of the strains. In most (71%) of the ß-lactamase producing strains, a penicillinase of the TEM type was observed; in 9% of the strains, all isolated since 1985, a CARB-type penicillinase with a pI 6·3 was observed. The presence of a cephalosporinase type enzyme was detected in acinetobacter strains isolated since 1981 and its incidence increased in 1986. Multiple ß-lactamases (penicillinase plus cephalosporinase) were observed in 32% of the strains.
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