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Journal of Antimicrobial Chemotherapy (1988) 21, 801-805
© 1988 The British Society for Antimicrobial Chemotherapy

research-article

Topically applied vidarabine sodium phosphate in genital herpes infection

Lawrence J. Erona,, Lisa Harveya and Jimmie Gleasonb

aDivision of Infectious Disease, The Fairfax Hospital Falls Church, VA, 22046 bThe Stormont-Vail Regional Medical Center Topeka, KA, USA

Received 9 July 1987; accepted 2 February 1988

Corresponding author Dr Lawrence J. Eron, 3299 Woodburn Road, Annandale, Virginia 22003, USA

One hundred and thirty-four patients with recurrences of genital herpes were randomized in a double-blind trial to receive self-applied topical therapy with either vidarabine sodium phosphate in an aqueous gel or placebo gel. No significant differences were noted between the two groups in the duration of viral shedding, in the time to healing of the treated recurrence, in the interval between recurrences, or in the number of recurrences.


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