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Journal of Antimicrobial Chemotherapy (1988) 21, 795-799
© 1988 The British Society for Antimicrobial Chemotherapy

research-article

Pefloxacin in the treatment of nosocomial lower respiratory tract infections in intensive care patients

C. Martina, F. Gouina, F. Fourrierb, W. Jungingerd and B. L. Prieurc

aHôpital Sainte-Marguerite Marseille bHôpital B. Lille cRhône-Poulen Santé France dTübingen University Tübingen, Federal Republic of Germany

Received 2 December 1987; accepted 28 January 1988

Pefloxacin was used to treat nosocomial pulmonary infections in 46 mechanically ventilated patients. All patients had one or more underlying diseases and were given pefloxacin at a dose of 800 mg or 1200 mg daily in two or three divided doses. The commonest bacterial isolates were Staphylococcus aureus, Pseudomanas aeruginosa and enterobacteria. Of these patients, 33 (72%) showed a favourable response, one patient relapsed and 12 (26%) were considered failures. Superinfections occurred in 10 (22%). Of the 62 isolated potential pathogens, 53 (85%) were completely eradicated. Side effects were mild and treatment was withdrawn in only three patients. Pefloxacin can be considered as a possible therapeutic agent for the treatment of nosocomial pulmonary infections.


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