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Journal of Antimicrobial Chemotherapy (1988) 21, 755-763
© 1988 The British Society for Antimicrobial Chemotherapy

research-article

Inhibition of adherence of Candida albicans by conventional and experimental antifungal drugs

Varaporn Vuddhakul, Joseph G. McCormack, W. Kim Seow, Susan E. Smith and Y. H. Thong

Immunobiology Laboratory, Departments of Child Health and Medicine, University of Queensland, Mater Public Hospital South Brisbane 4101, Australia

Received 15 October 1987; accepted 27 January 1988

Correspondence to: Professor Y. H. Thong

We tested the effects of antifungal drugs on adherence of Candida albicans in vitro. Significant reduction of adherence occurred after 2 h incubation with amphotericin B, nystatin, miconazole, econazole, ketoconazole, chlorohexidine and ICI 195,739. Significant inhibition of Candida adherence by 5-fluorocytosine and amorolfin required 18 h incubation. Combinations of amphotericin B with 5-fluorocytosine, miconazole, ICI 195,739 and amorolfin resulted in synergistic inhibition of adherence. Adherence is an important pathogenic mechanism in Candida infections and interference with this process may represent a major component of the mode of action of antifungal drugs.


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