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Journal of Antimicrobial Chemotherapy (1987) 20, 887-892
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Intranasal chalcone, Ro 09–0410, as prophylaxis against rhinovirus infection in human volunteers

W. Al-Nakib, P. G. Higgins, I. Barrow, D. A. J. Tyrrela, I. Lenox-Smithb and H. Ishitsukac

aMRC Common Cold Unit, Harvard Hospital Salisbury, Wiltshire bRoche Products Ltd. Welwyn Garden City, Hertfordshire, U.K. cNippon Roche KK Kamakura, Japan

accepted 21 July 1987

The antirhinovirus agent chalcone Ro 09–0410 was tested in double-blind place-controlled volunteer trials for its protective efficacy against experimental rhinovirus infection. Fifty volunteers received either drug (26 volunteers) or placebo (24 volunteers) both before and after challenge with 20–40 tissue culture infecting dose (TCID50) of human rhinovirus 2 (RV2). There was no evidence that medication significantly reduced the incidence of infection or illness, indeed there was some increase in the nasal secretion produced.


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