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Journal of Antimicrobial Chemotherapy (1987) 20, 871-874
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Effect of imipenem (N-formimidoyl-thienamycin) on the in-vitro lymphocyte proliferation

J.-C. Petit, B. Burghoffer, G. Richard and G.-L. Daguet

Department of Bacteriology, Faculty of Medicine Saint-Antoine 75571 Paris Cedex 12, France

accepted 27 July 1987

Imipenem, a new carbapenem, was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohacmagglutinin-stimulated and unstimulated proliferation (measured by 3H-thymidine uptake) of murine splenocytes and thymocytes. Addition of imipenem at concentrations of 10–50 mg/l induced lymphocyte transformation in unstimulated and mitogen-stimulated lymphocytes. Since imipenem stimulated blastogenesis at concentrations achievable in serum when used therapeutically, these results may have potential clinical significance.


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