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Journal of Antimicrobial Chemotherapy (1987) 20, 849-855
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Interaction of ceftriaxone with human polymorphonuclear neutrophil function

M.T. Labroa, C. Babin-Chevayea, I. Pochetb and J. Hakima

aINSERM U. 294 and Laboratoire d'Immunologie et d'Hématologie, Centre Hospitalo-Universitaire Xavier Bichat 46, rue Henri Huchard, 75018 Paris, France bLaboratoires Produit Roche 52, boulevard du Parc, 92521 Neuilly Sur Seine, France

accepted 16 June 1987

Ceftriaxone, an amino-2-thiazolyl cephalosporin, has been shown to cooperate in vitrowith human neutrophils for the killing of some bacteria. In this work the direct interaction with human leucocyte bactericidal function has been studied. Ceftriaxone (1000 to 1 mg/l) did not alter neutrophil chemotaxis or superoxide anion production. It also did not interfere with the chemiluminescence response of isolated PMN although a paradoxical depressive effect was observed with whole human blood in the case of zymosan stimulation. The killing ofStaphylococcus aureusandKlebsiella pneumoniaewas not enhanced by ceftriaxone and phagocytosis was significantly depressed only with adherent neutrophils but not when using neutrophils in liquid medium. It is concluded that the synergy observed between leucocyte and ceftriaxone for bacterial killing cannot be related to a direct stimulation of neutrophil functions and should depend on bacterial alteration.


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