Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Paull, A.
Right arrow Articles by Marks, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paull, A.
Right arrow Articles by Marks, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1987) 20, 831-838
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

A new method for the determination of bactericidal antibiotic synergy

A. Paull and J. Marks

Department of Medical Microbiology and Department of Surgery, University of Wales College of Medicine Heath Park, Cardiff CF4 4XN, U.K.

accepted 7 July 1987

Current methods of measuring bactericidal antibiotic synergy are particularly susceptible to error because of their use of arbitrary endpoints and criteria; their results are not easily tested for statistical significance and the procedures require considerable time and effort. A single-stage method is described in which bacteria are exposed to antibiotics for a short period and then transferred twice to drug-free medium by means of a filter membrane. The results are available the next day in the form of survival counts which can be compared statistically. In an examination of 21 strains of faecal streptococcus exposed to penicillin and gentamicin the bactericidal synergy observed was smoothly variable, a finding with a bearing on the management of infections with this organism, in that the recognition of strains showing an intermediate degree of synergy is possible.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.